CC Genotype of <i>GNAS</i> c.393C>T (rs7121) Polymorphism Has a Protective Effect against Development of BK Viremia and BKV-Associated Nephropathy after Renal Transplant

CC Genotype of <i>GNAS</i> c.393C>T (rs7121) Polymorphism Has a Protective Effect against Development of BK Viremia and BKV-Associated Nephropathy after Renal Transplant

The <i>GNAS</i> gene encodes the alpha-subunit of the stimulatory G-protein (Gαs) in humans and mice. The single-nucleotide polymorphism of <i>GNAS</i>, c.393C>T, is associated with an elevated production of Gαs and an increased formation of cyclic adenosine monophosphate...

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Bibliographic Details
Main Authors: Tobias Peitz, Birte Möhlendick, Ute Eisenberger, Winfried Siffert, Falko Markus Heinemann, Andreas Kribben, Justa Friebus-Kardash
Format: Article
Language:English
Published: MDPI AG 2022-10-01
Series:Pathogens
Subjects:
<i>GNAS</i> c.393C>T polymorphism
renal transplantation
BK viremia
BKV-associated nephropathy
de novo donor specific antibodies
Online Access:https://www.mdpi.com/2076-0817/11/10/1138

Internet

https://www.mdpi.com/2076-0817/11/10/1138

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