An intragenic SRF-dependent regulatory motif directs cardiac-specific microRNA-1-1/133a-2 expression.

An intragenic SRF-dependent regulatory motif directs cardiac-specific microRNA-1-1/133a-2 expression.

Transcriptional regulation is essential for any gene expression including microRNA expression. MiR-1-1 and miR-133a-2 are essential microRNAs (miRs) involved in cardiac and skeletal muscle development and diseases. Early studies reveal two regulatory enhancers, an upstream and an intragenic, that di...

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Bibliographic Details
Main Authors: Qi Li, Junli Guo, Xi Lin, Xiangsheng Yang, Yanlin Ma, Guo-Chang Fan, Jiang Chang
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3772891?pdf=render

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http://europepmc.org/articles/PMC3772891?pdf=render

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