The clinical and genomic distinctions of Class1/2/3 BRAF-mutant colorectal cancer and differential prognoses

The clinical and genomic distinctions of Class1/2/3 BRAF-mutant colorectal cancer and differential prognoses

Abstract BRAF mutations are the oncogenic drivers in colorectal cancer and V600 mutations (Class1), which lead to RAS-independent active monomers, are the most common mutation types. BRAF non-V600 mutants can be further classified as RAS-independent active dimers (Class2) and RAS-dependent impaired...

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Bibliographic Details
Main Authors: Yungchang Chen, Hao Sun, Yanhong Deng, Yutong Ma, He Huang, Yang Liu, Yaru Zhang, Hongyu Zhang, Sheng Ye, Mingyan E, Hongqiang Guo, Mengmeng Wu, Chunman Wu, Xingxiang Pu, Xinggui Chen, Chaoyong Liang, Qiuxiang Ou, Huawei Weng, Xue Wu, Yang Shao, Anxin Gu, Tongyu Lin
Format: Article
Language:English
Published: BMC 2023-01-01
Series:Biomarker Research
Subjects:
BRAF
Colorectal cancer
Next-generation sequencing
Prognosis
Online Access:https://doi.org/10.1186/s40364-022-00443-8

Internet

https://doi.org/10.1186/s40364-022-00443-8

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