Cuprizone-Induced Neurotoxicity in Human Neural Cell Lines Is Mediated by a Reversible Mitochondrial Dysfunction: Relevance for Demyelination Models

Suitable in vivo and in vitro models are instrumental for the development of new drugs aimed at improving symptoms or progression of multiple sclerosis (MS). The cuprizone (CPZ)-induced murine model has gained momentum in recent decades, aiming to address the demyelination component of the disease....

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Bibliographic Details
Main Authors: Eva Martínez-Pinilla, Núria Rubio-Sardón, Sandra Villar-Conde, Gemma Navarro, Eva del Valle, Jorge Tolivia, Rafael Franco, Ana Navarro
Format: Article
Language:English
Published: MDPI AG 2021-02-01
Series:Brain Sciences
Subjects:
Online Access:https://www.mdpi.com/2076-3425/11/2/272