Selection of Aspergillus fumigatus isolates carrying the G448S substitution in CYP51A gene after long-term treatment with voriconazole in an immunocompromised patient
We present a case of a 55-year-old man with a heart transplant who acquired Invasive Aspergillosis by Aspergillus fumigatus with the focus in the kidney. During about two years of antifungal treatment, most of the time with voriconazole, it was possible to obtain nine isolates of A. fumigatus, with...
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| Format: | Article |
| Language: | English |
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Elsevier
2022-06-01
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| Series: | Medical Mycology Case Reports |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2211753922000094 |
| _version_ | 1818550923963662336 |
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| author | Laís Pontes Caio Augusto Gualtieri Beraquet Teppei Arai Akira Watanabe Maria Luiza Moretti Angelica Zaninelli Schreiber |
| author_facet | Laís Pontes Caio Augusto Gualtieri Beraquet Teppei Arai Akira Watanabe Maria Luiza Moretti Angelica Zaninelli Schreiber |
| author_sort | Laís Pontes |
| collection | DOAJ |
| description | We present a case of a 55-year-old man with a heart transplant who acquired Invasive Aspergillosis by Aspergillus fumigatus with the focus in the kidney. During about two years of antifungal treatment, most of the time with voriconazole, it was possible to obtain nine isolates of A. fumigatus, with the same genotypic characteristics, but with an increase in MIC for several azoles. The two last isolates presented high MICs for Voriconazole (>8 μg/mL>). Sequencing of the CYP51A gene showed G448S amino acid substitution in the same two isolates. In long-term treatments with antifungals, it would be important to regularly evaluate the susceptibility of isolated strains, as resistance to azoles has been increasingly described around the world. |
| first_indexed | 2024-12-12T08:53:01Z |
| format | Article |
| id | doaj.art-b5cbffddc4ed4f9eba2de412e6998609 |
| institution | Directory Open Access Journal |
| issn | 2211-7539 |
| language | English |
| last_indexed | 2024-12-12T08:53:01Z |
| publishDate | 2022-06-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Medical Mycology Case Reports |
| spelling | doaj.art-b5cbffddc4ed4f9eba2de412e69986092022-12-22T00:30:08ZengElsevierMedical Mycology Case Reports2211-75392022-06-013659Selection of Aspergillus fumigatus isolates carrying the G448S substitution in CYP51A gene after long-term treatment with voriconazole in an immunocompromised patientLaís Pontes0Caio Augusto Gualtieri Beraquet1Teppei Arai2Akira Watanabe3Maria Luiza Moretti4Angelica Zaninelli Schreiber5School of Medical Sciences - University of Campinas, Campinas, Sao Paulo, BrazilSchool of Medical Sciences - University of Campinas, Campinas, Sao Paulo, BrazilDivision of Clinical Research, Medical Mycology Research Center – Chiba University, Chiba, JapanDivision of Clinical Research, Medical Mycology Research Center – Chiba University, Chiba, JapanSchool of Medical Sciences - University of Campinas, Campinas, Sao Paulo, BrazilSchool of Medical Sciences - University of Campinas, Campinas, Sao Paulo, Brazil; Corresponding author. Pathology Department, School of Medical Sciences, University of Campinas, Brazil.We present a case of a 55-year-old man with a heart transplant who acquired Invasive Aspergillosis by Aspergillus fumigatus with the focus in the kidney. During about two years of antifungal treatment, most of the time with voriconazole, it was possible to obtain nine isolates of A. fumigatus, with the same genotypic characteristics, but with an increase in MIC for several azoles. The two last isolates presented high MICs for Voriconazole (>8 μg/mL>). Sequencing of the CYP51A gene showed G448S amino acid substitution in the same two isolates. In long-term treatments with antifungals, it would be important to regularly evaluate the susceptibility of isolated strains, as resistance to azoles has been increasingly described around the world.http://www.sciencedirect.com/science/article/pii/S2211753922000094Aspergillus fumigatusInvasive aspergillosisAzole-resistanceBrazil |
| spellingShingle | Laís Pontes Caio Augusto Gualtieri Beraquet Teppei Arai Akira Watanabe Maria Luiza Moretti Angelica Zaninelli Schreiber Selection of Aspergillus fumigatus isolates carrying the G448S substitution in CYP51A gene after long-term treatment with voriconazole in an immunocompromised patient Medical Mycology Case Reports Aspergillus fumigatus Invasive aspergillosis Azole-resistance Brazil |
| title | Selection of Aspergillus fumigatus isolates carrying the G448S substitution in CYP51A gene after long-term treatment with voriconazole in an immunocompromised patient |
| title_full | Selection of Aspergillus fumigatus isolates carrying the G448S substitution in CYP51A gene after long-term treatment with voriconazole in an immunocompromised patient |
| title_fullStr | Selection of Aspergillus fumigatus isolates carrying the G448S substitution in CYP51A gene after long-term treatment with voriconazole in an immunocompromised patient |
| title_full_unstemmed | Selection of Aspergillus fumigatus isolates carrying the G448S substitution in CYP51A gene after long-term treatment with voriconazole in an immunocompromised patient |
| title_short | Selection of Aspergillus fumigatus isolates carrying the G448S substitution in CYP51A gene after long-term treatment with voriconazole in an immunocompromised patient |
| title_sort | selection of aspergillus fumigatus isolates carrying the g448s substitution in cyp51a gene after long term treatment with voriconazole in an immunocompromised patient |
| topic | Aspergillus fumigatus Invasive aspergillosis Azole-resistance Brazil |
| url | http://www.sciencedirect.com/science/article/pii/S2211753922000094 |
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