Effect of apolipoprotein E ε4 allele on the progression of cognitive decline in the early stage of Alzheimer's disease

Effect of apolipoprotein E ε4 allele on the progression of cognitive decline in the early stage of Alzheimer's disease

Abstract Introduction Possession of the apolipoprotein E (APOE) ε4 allele advances amyloid β (Aβ) deposition and symptomatic onset of Alzheimer's disease (AD), whereas its effect on the rate of cognitive decline remained controversial. We examined the effects of APOE ε4 allele on cognition in b...

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Bibliographic Details
Main Authors: Kazushi Suzuki, Akihiro Hirakawa, Ryoko Ihara, Atsushi Iwata, Kenji Ishii, Takeshi Ikeuchi, Chung‐Kai Sun, Michael Donohue, Takeshi Iwatsubo, Alzheimer's Disease Neuroimaging Initiative, Japanese Alzheimer's Disease Neuroimaging Initiative
Format: Article
Language:English
Published: Wiley 2020-01-01
Series:Alzheimer’s & Dementia: Translational Research & Clinical Interventions
Subjects:
ADNI
amyloid PET
APOE
CSF biomarkers
early Alzheimer's disease
J‐ADNI
Online Access:https://doi.org/10.1002/trc2.12007

Internet

https://doi.org/10.1002/trc2.12007

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