Enhanced axon outgrowth of spinal motor neurons in co-culturing with dorsal root ganglions antagonizes the growth inhibitory environment

Enhanced axon outgrowth of spinal motor neurons in co-culturing with dorsal root ganglions antagonizes the growth inhibitory environment

Introduction: Forming a bridge made of functional axons to span the lesion is essential to reconstruct the motor circuitry following spinal cord injury (SCI). Dorsal root ganglion (DRG) axons are robust in axon growth and have been proved to facilitate the growth of cortical neurons in a process of...

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Bibliographic Details
Main Authors: Zi-Xing Xu, Dan Xu, Fang Fang, Ying-Juan Fan, Bing Wu, Yu-Fan Chen, Hao-En Huang, Xin-Hao Huang, Yue-Hong Zhuang, Wei-Hong Xu
Format: Article
Language:English
Published: Elsevier 2024-03-01
Series:Regenerative Therapy
Subjects:
Central nervous system regeneration
Spinal motor neuron aggregates
Dorsal root ganglia transplantation
Experimental modeling
Axonal bridging
3D printing
Online Access:http://www.sciencedirect.com/science/article/pii/S2352320423001323

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http://www.sciencedirect.com/science/article/pii/S2352320423001323

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