Identification of potential COVID-19 main protease inhibitors using structure-based pharmacophore approach, molecular docking and repurposing studies

Identification of potential COVID-19 main protease inhibitors using structure-based pharmacophore approach, molecular docking and repurposing studies

The current outbreak of novel coronavirus (COVID-19) infections urges the need to identify potential therapeutic agents. Therefore, the repurposing of FDA-approved drugs against today’s diseases involves the use of de-risked compounds with potentially lower costs and shorter development timelines. I...

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Bibliographic Details
Main Authors: Daoud Safa, Alabed Shada J., Dahabiyeh Lina A.
Format: Article
Language:English
Published: Sciendo 2021-06-01
Series:Acta Pharmaceutica
Subjects:
covid-19
main protease
pharmacophore
structure-based modeling
docking study
remdesivir
repurposing
Online Access:https://doi.org/10.2478/acph-2021-0016

Internet

https://doi.org/10.2478/acph-2021-0016

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