Stage-Dependent Activity and Pro-Chondrogenic Function of PI3K/AKT during Cartilage Neogenesis from Mesenchymal Stromal Cells

Stage-Dependent Activity and Pro-Chondrogenic Function of PI3K/AKT during Cartilage Neogenesis from Mesenchymal Stromal Cells

Differentiating mesenchymal stromal cells (MSCs) into articular chondrocytes (ACs) for application in clinical cartilage regeneration requires a profound understanding of signaling pathways regulating stem cell chondrogenesis and hypertrophic degeneration. Classifying endochondral signals into drive...

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Bibliographic Details
Main Authors: Felicia A. M. Klampfleuthner, Benedict Lotz, Tobias Renkawitz, Wiltrud Richter, Solvig Diederichs
Format: Article
Language:English
Published: MDPI AG 2022-09-01
Series:Cells
Subjects:
mesenchymal stromal cells
chondrogenesis
cartilage
chondrocyte hypertrophy
PI3K
AKT
Online Access:https://www.mdpi.com/2073-4409/11/19/2965

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https://www.mdpi.com/2073-4409/11/19/2965

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