Chronic alcohol administration alters metabolomic profile of murine bone marrow

Chronic alcohol administration alters metabolomic profile of murine bone marrow

IntroductionPeople with hazardous alcohol use are more susceptible to viral, bacterial, and fungal infections due to the effect of alcohol on immune system cell function. Metabolized ethanol reduces NAD+ to NADH, affecting critical metabolic pathways. Here, our aim was to investigate whether alcohol...

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Main Authors: Tássia Tatiane Pontes Pereira, Filipe Fideles Duarte-Andrade, Jéssica Gardone Vitório, Taiane do Espírito Santo Pereira, Flavia Rayssa Braga Martins, Jéssica Amanda Marques Souza, Nathália Luisa Malacco, Eliza Mathias Melo, Carolina Raíssa Costa Picossi, Ernani Pinto, Ricardo Santiago Gomez, Mauro Martins Teixeira, Adriana Nori de Macedo, Gisele André Baptista Canuto, Frederico Marianetti Soriani
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-04-01
Series:Frontiers in Immunology
Subjects:
alcoholism
bone marrow
metabolome
cell function
metabolites
immune system
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2023.1128352/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2023.1128352/full

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