Cross interactions between Apolipoprotein E and amyloid proteins in neurodegenerative diseases

Cross interactions between Apolipoprotein E and amyloid proteins in neurodegenerative diseases

Three common Apolipoprotein E isoforms, ApoE2, ApoE3, and ApoE4, are key regulators of lipid homeostasis, among other functions. Apolipoprotein E can interact with amyloid proteins. The isoforms differ by one or two residues at positions 112 and 158, and possess distinct structural conformations and...

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Bibliographic Details
Main Authors: Rolf Antonie Loch, Hongzhi Wang, Alex Perálvarez-Marín, Philipp Berger, Henrietta Nielsen, Angeliki Chroni, Jinghui Luo
Format: Article
Language:English
Published: Elsevier 2023-01-01
Series:Computational and Structural Biotechnology Journal
Subjects:
ApoE
Amyloid proteins
Interaction
Endogenous molecules
Cytotoxicity
Therapeutics
Online Access:http://www.sciencedirect.com/science/article/pii/S2001037023000223

Internet

http://www.sciencedirect.com/science/article/pii/S2001037023000223

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