Cell Cycle Arrest and Apoptosis-Inducing Ability of Benzimidazole Derivatives: Design, Synthesis, Docking, and Biological Evaluation

Cell Cycle Arrest and Apoptosis-Inducing Ability of Benzimidazole Derivatives: Design, Synthesis, Docking, and Biological Evaluation

In the current study, new benzimidazole-based 1,3,4-oxadiazole derivatives have been synthesized and characterized by NMR, IR, MS, and elemental analysis. The final compounds were screened for cytotoxicity against MDA-MB-231, SKOV3, and A549 cell lines and EGFR for inhibitory activities. Compounds &...

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Bibliographic Details
Main Authors: Syed Nazreen, Abdulraheem S. A. Almalki, Serag Eldin I. Elbehairi, Ali A. Shati, Mohammad Y. Alfaifi, Ahmed A. Elhenawy, Nawaf I. Alsenani, Anas Alfarsi, Abdulrahman Alhadhrami, Esam A. Alqurashi, Mohammad Mahboob Alam
Format: Article
Language:English
Published: MDPI AG 2022-10-01
Series:Molecules
Subjects:
1,3,4-oxadiazole
benzimidazole
cell cycle arrest
apoptosis
docking
Online Access:https://www.mdpi.com/1420-3049/27/20/6899

Internet

https://www.mdpi.com/1420-3049/27/20/6899

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