Drosophila Ube3a regulates monoamine synthesis by increasing GTP cyclohydrolase I activity via a non-ubiquitin ligase mechanism

Drosophila Ube3a regulates monoamine synthesis by increasing GTP cyclohydrolase I activity via a non-ubiquitin ligase mechanism

The underlying defects in Angelman syndrome (AS) and autism spectrum disorder (ASD) may be in part due to basic defects in synaptic plasticity and function. In some individuals serotonin reuptake inhibitors, which decrease pre-synaptic re-uptake of serotonin, can ameliorate symptoms, as can resperid...

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Bibliographic Details
Main Authors: Faiza Ferdousy, William Bodeen, Kyle Summers, Olugbenga Doherty, O'Neil Wright, Nahed Elsisi, George Hilliard, Janis M. O'Donnell, Lawrence T. Reiter
Format: Article
Language:English
Published: Elsevier 2011-03-01
Series:Neurobiology of Disease
Subjects:
UBE3A
Angelman syndrome
Autism
Dopamine
GTPCH1
Ubiquitin ligase activity
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996110003943

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http://www.sciencedirect.com/science/article/pii/S0969996110003943

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