Detection of in vivo mutagenicity in rat liver samples using error-corrected sequencing techniques

Abstract Background Mutagenicity, the ability of chemical agents to cause mutations and potentially lead to cancer, is a critical aspect of substance safety assessment for protecting human health and the environment. Metabolic enzymes activate multiple mutagens in living organisms, thus in vivo anim...

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Bibliographic Details
Main Authors: Kazuki Izawa, Masataka Tsuda, Takayoshi Suzuki, Masamitsu Honma, Kei-ichi Sugiyama
Format: Article
Language:English
Published: BMC 2023-11-01
Series:Genes and Environment
Subjects:
Online Access:https://doi.org/10.1186/s41021-023-00288-z