Alpha-Soluble NSF Attachment Protein Prevents the Cleavage of the SARS-CoV-2 Spike Protein by Functioning as an Interferon-Upregulated Furin Inhibitor

Alpha-Soluble NSF Attachment Protein Prevents the Cleavage of the SARS-CoV-2 Spike Protein by Functioning as an Interferon-Upregulated Furin Inhibitor

ABSTRACT Loss of the furin cleavage motif in the SARS-CoV-2 spike protein reduces the virulence and transmission of SARS-CoV-2, suggesting that furin is an attractive antiviral drug target. However, lack of understanding of the regulation of furin activity has largely limited the development of furi...

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Bibliographic Details
Main Authors: Jinliang Wang, Jie Luo, Zhiyuan Wen, Xinxin Wang, Lei Shuai, Gongxun Zhong, Chong Wang, Ziruo Sun, Weiye Chen, Jinying Ge, Renqiang Liu, Xijun Wang, Zhigao Bu
Format: Article
Language:English
Published: American Society for Microbiology 2022-02-01
Series:mBio
Subjects:
SARS-CoV-2 spike protein
cleavage
alpha-soluble NSF attachment protein
furin inhibitor
interferon upregulated
Online Access:https://journals.asm.org/doi/10.1128/mbio.02443-21

Internet

https://journals.asm.org/doi/10.1128/mbio.02443-21

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