Nucleation of α-Synuclein Amyloid Fibrils Induced by Cross-Interaction with β-Hairpin Peptides Derived from Immunoglobulin Light Chains

Nucleation of α-Synuclein Amyloid Fibrils Induced by Cross-Interaction with β-Hairpin Peptides Derived from Immunoglobulin Light Chains

Heterologous interactions between different amyloid-forming proteins, also called cross-interactions, may have a critical impact on disease-related amyloid formation. β-hairpin conformers of amyloid-forming proteins have been shown to affect homologous interactions in the amyloid self-assembly proce...

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Bibliographic Details
Main Authors: Laetitia F. Heid, Tatsiana Kupreichyk, Marie P. Schützmann, Walfried Schneider, Matthias Stoldt, Wolfgang Hoyer
Format: Article
Language:English
Published: MDPI AG 2023-11-01
Series:International Journal of Molecular Sciences
Subjects:
β-hairpin
cross-seeding
synucleinopathy
AL amyloidosis
primary nucleation
secondary nucleation
Online Access:https://www.mdpi.com/1422-0067/24/22/16132

Internet

https://www.mdpi.com/1422-0067/24/22/16132

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