Intranasal Vaccination with Recombinant TLR2-Active Outer Membrane Vesicles Containing Sequential M2e Epitopes Protects against Lethal Influenza a Challenge

Intranasal Vaccination with Recombinant TLR2-Active Outer Membrane Vesicles Containing Sequential M2e Epitopes Protects against Lethal Influenza a Challenge

Influenza is a highly contagious respiratory disease, resulting in an estimated 3 to 5 million cases of severe illness annually. While most influenza vaccines are administered parenterally via injection, one shortcoming is that they do not generate a strong immune response at the site of infection,...

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Bibliographic Details
Main Authors: Nisha Kannan, Annette Choi, Mariela A. Rivera De Jesus, Peter Male Wei, Julie Marie Sahler, Stephanie Marie Curley, Avery August, Matthew P. DeLisa, Gary R. Whittaker, David Putnam
Format: Article
Language:English
Published: MDPI AG 2024-06-01
Series:Vaccines
Subjects:
intranasal vaccine
influenza
OMV vaccine
Online Access:https://www.mdpi.com/2076-393X/12/7/724

Internet

https://www.mdpi.com/2076-393X/12/7/724

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