Age-related changes in the BACH2 and PRDM1 genes in lymphocytes from healthy donors and chronic lymphocytic leukemia patients

Age-related changes in the BACH2 and PRDM1 genes in lymphocytes from healthy donors and chronic lymphocytic leukemia patients

Abstract Background Age-related genetic changes in lymphocyte subsets are not currently well documented. BACH2 is a transcription factor that plays an important role in immune-mediated homeostasis by tightly regulating PRDM1 expression in both B-cells and T-cells. BACH2 gene expression is highly sen...

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Bibliographic Details
Main Authors: Vu Luan Dang Chi, Soizic Garaud, Pushpamali De Silva, Vincent Thibaud, Basile Stamatopoulos, Mimoune Berehad, Chunyan Gu-Trantien, Mohammad Krayem, Hugues Duvillier, Jean-Nicolas Lodewyckx, Karen Willard-Gallo, Catherine Sibille, Dominique Bron
Format: Article
Language:English
Published: BMC 2019-01-01
Series:BMC Cancer
Subjects:
BACH2
PRDM1
Immunosenescence
Chronic lymphocytic leukemia
Lymphocytes
Apoptosis
Online Access:http://link.springer.com/article/10.1186/s12885-019-5276-2

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http://link.springer.com/article/10.1186/s12885-019-5276-2

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