Recombinant Tissue Plasminogen Activator (r-tPA) Induces In-Vitro Human Neutrophil Migration via Low Density Lipoprotein Receptor-Related Protein 1 (LRP-1)

Recombinant Tissue Plasminogen Activator (r-tPA) Induces In-Vitro Human Neutrophil Migration via Low Density Lipoprotein Receptor-Related Protein 1 (LRP-1)

Thrombolysis is the gold standard treatment for acute ischemic stroke. Besides its fibrinolytic role, recombinant tissue plasminogen activator (r-tPA) holds several non-fibrinolytic functions. Here, we investigated the potential role of r-tPA on human primary neutrophil migration in vitro. By means...

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Bibliographic Details
Main Authors: Luca Liberale, Maria Bertolotto, Silvia Minetti, Paola Contini, Daniela Verzola, Pietro Ameri, Giorgio Ghigliotti, Aldo Pende, Giovanni G. Camici, Federico Carbone, Fabrizio Montecucco
Format: Article
Language:English
Published: MDPI AG 2020-09-01
Series:International Journal of Molecular Sciences
Subjects:
tissue plasminogen activator
neutrophil
inflammation
Online Access:https://www.mdpi.com/1422-0067/21/19/7014

Internet

https://www.mdpi.com/1422-0067/21/19/7014

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