Impaired Autophagic Clearance with a Gain-of-Function Variant of the Lysosomal Cl<sup>−</sup>/H<sup>+</sup> Exchanger ClC-7

Impaired Autophagic Clearance with a Gain-of-Function Variant of the Lysosomal Cl<sup>−</sup>/H<sup>+</sup> Exchanger ClC-7

ClC-7 is a ubiquitously expressed voltage-gated Cl<sup>−</sup>/H<sup>+</sup> exchanger that critically contributes to lysosomal ion homeostasis. Together with its β-subunit Ostm1, ClC-7 localizes to lysosomes and to the ruffled border of osteoclasts, where it supports the aci...

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Bibliographic Details
Main Authors: Shroddha Bose, Cecilia de Heus, Mary E. Kennedy, Fan Wang, Thomas J. Jentsch, Judith Klumperman, Tobias Stauber
Format: Article
Language:English
Published: MDPI AG 2023-12-01
Series:Biomolecules
Subjects:
autophagy
chloride/proton exchange
ClC-7
endo-lysosomes
lysosomal storage disorder
osmotic pressure
Online Access:https://www.mdpi.com/2218-273X/13/12/1799

Internet

https://www.mdpi.com/2218-273X/13/12/1799

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