NF-κB-induced IL-6 ensures STAT3 activation and tumor aggressiveness in glioblastoma.

NF-κB-induced IL-6 ensures STAT3 activation and tumor aggressiveness in glioblastoma.

Glioblastoma (GBM) is the most aggressive, neurologically destructive and deadly tumor of the central nervous system (CNS). In GBM, the transcription factors NF-κB and STAT3 are aberrantly activated and associated with tumor cell proliferation, survival, invasion and chemoresistance. In addition, co...

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Bibliographic Details
Main Authors: Braden C McFarland, Suk W Hong, Rajani Rajbhandari, George B Twitty, G Kenneth Gray, Hao Yu, Etty N Benveniste, Susan E Nozell
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3823708?pdf=render

Internet

http://europepmc.org/articles/PMC3823708?pdf=render

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