Multifactor dimensionality reduction method identifies novel SNP interactions in the WNT protein interaction networks that are associated with recurrence risk in colorectal cancer

Multifactor dimensionality reduction method identifies novel SNP interactions in the WNT protein interaction networks that are associated with recurrence risk in colorectal cancer

BackgroundInteractions among genetic variants are rarely studied but may explain a part of the variability in patient outcomes.ObjectivesIn this study, we aimed to identify 1 to 3 way interactions among SNPs from five Wnt protein interaction networks that predict the 5-year recurrence risk in a coho...

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Bibliographic Details
Main Authors: Aaron A. Curtis, Yajun Yu, Megan Carey, Patrick Parfrey, Yildiz E. Yilmaz, Sevtap Savas
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-03-01
Series:Frontiers in Oncology
Subjects:
Wnt pathway
recurrence
multifactor dimensionality reduction
SNP interactions
colorectal cancer
Online Access:https://www.frontiersin.org/articles/10.3389/fonc.2023.1122229/full

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https://www.frontiersin.org/articles/10.3389/fonc.2023.1122229/full

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