AGER-Mediated Lipid Peroxidation Drives Caspase-11 Inflammasome Activation in Sepsis

AGER-Mediated Lipid Peroxidation Drives Caspase-11 Inflammasome Activation in Sepsis

Inflammasome activation can trigger an inflammatory and innate immune response through the release of cytokines and induction of pyroptosis. A dysfunctional inflammasome has been implicated in the development of human pathologies, including sepsis and septic shock. Here, we show that advanced glycos...

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Bibliographic Details
Main Authors: Ruochan Chen, Shan Zhu, Ling Zeng, Qingde Wang, Yi Sheng, Borong Zhou, Daolin Tang, Rui Kang
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-08-01
Series:Frontiers in Immunology
Subjects:
DAMP
AGER
ALOX5
caspase-11
sepsis
inflammasome
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2019.01904/full

Internet

https://www.frontiersin.org/article/10.3389/fimmu.2019.01904/full

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