Cognitive Decline Related to Diet Pattern and Nutritional Adequacy in Alzheimer’s Disease Using Surface-Based Morphometry
Dietary pattern (DP) results in nutrition adequacy and may influence cognitive decline and cortical atrophy in Alzheimer’s disease (AD). The study explored DP in 248 patients with AD. Two neurobehavioral assessments (intervals 13.4 months) and two cortical thickness measurements derived from magneti...
| Main Authors: | , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2022-12-01
|
| Series: | Nutrients |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2072-6643/14/24/5300 |
| _version_ | 1797455884553551872 |
|---|---|
| author | Hua-Tsen Hsiao Mi-Chia Ma Hsin-I Chang Ching-Heng Lin Shih-Wei Hsu Shu-Hua Huang Chen-Chang Lee Chi-Wei Huang Chiung-Chih Chang |
| author_facet | Hua-Tsen Hsiao Mi-Chia Ma Hsin-I Chang Ching-Heng Lin Shih-Wei Hsu Shu-Hua Huang Chen-Chang Lee Chi-Wei Huang Chiung-Chih Chang |
| author_sort | Hua-Tsen Hsiao |
| collection | DOAJ |
| description | Dietary pattern (DP) results in nutrition adequacy and may influence cognitive decline and cortical atrophy in Alzheimer’s disease (AD). The study explored DP in 248 patients with AD. Two neurobehavioral assessments (intervals 13.4 months) and two cortical thickness measurements derived from magnetic resonance images (intervals 26.5 months) were collected as outcome measures. Reduced rank regression was used to assess the groups of DPs and a linear mixed-effect model to explore the cortical neurodegenerative patterns. At screening, underweight body mass index (BMI) was related to significant higher lipid profile, impaired cognitive function, smaller cortical thickness, lower protein DP factor loading scores and the non-spouse caregiver status. Higher mini-mental state examination (MMSE) scores were related to the DP of coffee/tea, compared to the lipid/sugar or protein DP group. The underweighted-BMI group had faster cortical thickness atrophy in the pregenual and lateral temporal cortex, while the correlations between cortical thickness degeneration and high HbA1C or low B12 and folate levels were localized in the medial and lateral prefrontal cortex. The predictive model suggested that factors related to MMSE score were related to the caregiver status. In conclusion, normal or overweight BMI, coffee/tea DP group and living with a spouse were considered as protective factors for better cognitive outcomes in patients with AD. The influence of glucose, B12 and folate on the cortical degeneration was spatially distinct from the pattern of AD degeneration. |
| first_indexed | 2024-03-09T16:00:37Z |
| format | Article |
| id | doaj.art-b604fbdfd64d4553a1559d9cb676daa0 |
| institution | Directory Open Access Journal |
| issn | 2072-6643 |
| language | English |
| last_indexed | 2024-03-09T16:00:37Z |
| publishDate | 2022-12-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Nutrients |
| spelling | doaj.art-b604fbdfd64d4553a1559d9cb676daa02023-11-24T17:08:56ZengMDPI AGNutrients2072-66432022-12-011424530010.3390/nu14245300Cognitive Decline Related to Diet Pattern and Nutritional Adequacy in Alzheimer’s Disease Using Surface-Based MorphometryHua-Tsen Hsiao0Mi-Chia Ma1Hsin-I Chang2Ching-Heng Lin3Shih-Wei Hsu4Shu-Hua Huang5Chen-Chang Lee6Chi-Wei Huang7Chiung-Chih Chang8Department of Nursing, National Tainan Junior College of Nursing, Tainan 700007, TaiwanDepartment of Statistics and Institute of Data Science, National Cheng Kung University, Tainan 701401, TaiwanDepartment of Neurology, Cognition and Aging Center, Institute for Translational Research in Biomedicine, Kaohsiung Chang Gung Memorial Hospital, Chang Gung University College of Medicine, Kaohsiung 833401, TaiwanCenter for Artificial Intelligence in Medicine, Chang Gung Memorial Hospital, Taoyuan 333008, TaiwanDepartment of Radiology, Kaohsiung Chang Gung Memorial Hospital, Chang Gung University College of Medicine, Kaohsiung 833401, TaiwanDepartment of Nuclear Medicine, Kaohsiung Chang Gung Memorial Hospital, Chang Gung University College of Medicine, Kaohsiung 833401, TaiwanDepartment of Radiology, Kaohsiung Chang Gung Memorial Hospital, Chang Gung University College of Medicine, Kaohsiung 833401, TaiwanDepartment of Neurology, Cognition and Aging Center, Institute for Translational Research in Biomedicine, Kaohsiung Chang Gung Memorial Hospital, Chang Gung University College of Medicine, Kaohsiung 833401, TaiwanDepartment of Neurology, Cognition and Aging Center, Institute for Translational Research in Biomedicine, Kaohsiung Chang Gung Memorial Hospital, Chang Gung University College of Medicine, Kaohsiung 833401, TaiwanDietary pattern (DP) results in nutrition adequacy and may influence cognitive decline and cortical atrophy in Alzheimer’s disease (AD). The study explored DP in 248 patients with AD. Two neurobehavioral assessments (intervals 13.4 months) and two cortical thickness measurements derived from magnetic resonance images (intervals 26.5 months) were collected as outcome measures. Reduced rank regression was used to assess the groups of DPs and a linear mixed-effect model to explore the cortical neurodegenerative patterns. At screening, underweight body mass index (BMI) was related to significant higher lipid profile, impaired cognitive function, smaller cortical thickness, lower protein DP factor loading scores and the non-spouse caregiver status. Higher mini-mental state examination (MMSE) scores were related to the DP of coffee/tea, compared to the lipid/sugar or protein DP group. The underweighted-BMI group had faster cortical thickness atrophy in the pregenual and lateral temporal cortex, while the correlations between cortical thickness degeneration and high HbA1C or low B12 and folate levels were localized in the medial and lateral prefrontal cortex. The predictive model suggested that factors related to MMSE score were related to the caregiver status. In conclusion, normal or overweight BMI, coffee/tea DP group and living with a spouse were considered as protective factors for better cognitive outcomes in patients with AD. The influence of glucose, B12 and folate on the cortical degeneration was spatially distinct from the pattern of AD degeneration.https://www.mdpi.com/2072-6643/14/24/5300Alzheimer’s diseasecognitive declinediet patternblood biochemistrycortical thickness |
| spellingShingle | Hua-Tsen Hsiao Mi-Chia Ma Hsin-I Chang Ching-Heng Lin Shih-Wei Hsu Shu-Hua Huang Chen-Chang Lee Chi-Wei Huang Chiung-Chih Chang Cognitive Decline Related to Diet Pattern and Nutritional Adequacy in Alzheimer’s Disease Using Surface-Based Morphometry Nutrients Alzheimer’s disease cognitive decline diet pattern blood biochemistry cortical thickness |
| title | Cognitive Decline Related to Diet Pattern and Nutritional Adequacy in Alzheimer’s Disease Using Surface-Based Morphometry |
| title_full | Cognitive Decline Related to Diet Pattern and Nutritional Adequacy in Alzheimer’s Disease Using Surface-Based Morphometry |
| title_fullStr | Cognitive Decline Related to Diet Pattern and Nutritional Adequacy in Alzheimer’s Disease Using Surface-Based Morphometry |
| title_full_unstemmed | Cognitive Decline Related to Diet Pattern and Nutritional Adequacy in Alzheimer’s Disease Using Surface-Based Morphometry |
| title_short | Cognitive Decline Related to Diet Pattern and Nutritional Adequacy in Alzheimer’s Disease Using Surface-Based Morphometry |
| title_sort | cognitive decline related to diet pattern and nutritional adequacy in alzheimer s disease using surface based morphometry |
| topic | Alzheimer’s disease cognitive decline diet pattern blood biochemistry cortical thickness |
| url | https://www.mdpi.com/2072-6643/14/24/5300 |
| work_keys_str_mv | AT huatsenhsiao cognitivedeclinerelatedtodietpatternandnutritionaladequacyinalzheimersdiseaseusingsurfacebasedmorphometry AT michiama cognitivedeclinerelatedtodietpatternandnutritionaladequacyinalzheimersdiseaseusingsurfacebasedmorphometry AT hsinichang cognitivedeclinerelatedtodietpatternandnutritionaladequacyinalzheimersdiseaseusingsurfacebasedmorphometry AT chinghenglin cognitivedeclinerelatedtodietpatternandnutritionaladequacyinalzheimersdiseaseusingsurfacebasedmorphometry AT shihweihsu cognitivedeclinerelatedtodietpatternandnutritionaladequacyinalzheimersdiseaseusingsurfacebasedmorphometry AT shuhuahuang cognitivedeclinerelatedtodietpatternandnutritionaladequacyinalzheimersdiseaseusingsurfacebasedmorphometry AT chenchanglee cognitivedeclinerelatedtodietpatternandnutritionaladequacyinalzheimersdiseaseusingsurfacebasedmorphometry AT chiweihuang cognitivedeclinerelatedtodietpatternandnutritionaladequacyinalzheimersdiseaseusingsurfacebasedmorphometry AT chiungchihchang cognitivedeclinerelatedtodietpatternandnutritionaladequacyinalzheimersdiseaseusingsurfacebasedmorphometry |