Rapid GMP-Compliant Expansion of SARS-CoV-2–Specific T Cells From Convalescent Donors for Use as an Allogeneic Cell Therapy for COVID-19

Rapid GMP-Compliant Expansion of SARS-CoV-2–Specific T Cells From Convalescent Donors for Use as an Allogeneic Cell Therapy for COVID-19

COVID-19 disease caused by the SARS-CoV-2 virus is characterized by dysregulation of effector T cells and accumulation of exhausted T cells. T cell responses to viruses can be corrected by adoptive cellular therapy using donor-derived virus-specific T cells. One approach is the establishment of bank...

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Bibliographic Details
Main Authors: Rachel S. Cooper, Alasdair R. Fraser, Linda Smith, Paul Burgoyne, Stuart N. Imlach, Lisa M. Jarvis, David M. Turner, Sharon Zahra, Marc L. Turner, John D. M. Campbell
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-01-01
Series:Frontiers in Immunology
Subjects:
COVID-19
T cell
adoptive T cell immunotherapy
CD4
CD8
memory T cell
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2020.598402/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2020.598402/full

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