Amyloid-β Impairs Dendritic Trafficking of Golgi-Like Organelles in the Early Phase Preceding Neurite Atrophy: Rescue by Mirtazapine

Amyloid-β Impairs Dendritic Trafficking of Golgi-Like Organelles in the Early Phase Preceding Neurite Atrophy: Rescue by Mirtazapine

Neurite atrophy with loss of neuronal polarity is a pathological hallmark of Alzheimer’s disease (AD) and other neurological disorders. While there is substantial agreement that disruption of intracellular vesicle trafficking is associated with axonal pathology in AD, comparatively less is known reg...

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Bibliographic Details
Main Authors: Elsa Fabbretti, Giulia Antognolli, Enrico Tongiorgi
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-06-01
Series:Frontiers in Molecular Neuroscience
Subjects:
neurodegenerative disorders
amyloid-beta
neurite atrophy
neuronal polarity
Golgi-like organelles
intracellular vesicle trafficking
Online Access:https://www.frontiersin.org/articles/10.3389/fnmol.2021.661728/full

Internet

https://www.frontiersin.org/articles/10.3389/fnmol.2021.661728/full

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