Model-Informed Optimization of a Pediatric Clinical Pharmacokinetic Trial of a New Spironolactone Liquid Formulation

Model-Informed Optimization of a Pediatric Clinical Pharmacokinetic Trial of a New Spironolactone Liquid Formulation

Quantitative pharmacology brings important advantages in the design and conduct of pediatric clinical trials. Herein, we demonstrate the application of a model-based approach to select doses and pharmacokinetic sampling scenarios for the clinical evaluation of a novel oral suspension of spironolacto...

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Bibliographic Details
Main Authors: Manasa Tatipalli, Vijay Kumar Siripuram, Tao Long, Diana Shuster, Galina Bernstein, Pierre Martineau, Kim A. Cook, Rodrigo Cristofoletti, Stephan Schmidt, Valvanera Vozmediano
Format: Article
Language:English
Published: MDPI AG 2021-06-01
Series:Pharmaceutics
Subjects:
spironolactone
pediatrics
model informed drug development
better medicines for children
pharmacometrics
pediatric drugs
Online Access:https://www.mdpi.com/1999-4923/13/6/849

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https://www.mdpi.com/1999-4923/13/6/849

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