White matter abnormalities in the Hdc knockout mouse, a model of tic and OCD pathophysiology

White matter abnormalities in the Hdc knockout mouse, a model of tic and OCD pathophysiology

IntroductionAn inactivating mutation in the histidine decarboxylase gene (Hdc) has been identified as a rare but high-penetrance genetic cause of Tourette syndrome (TS). TS is a neurodevelopmental syndrome characterized by recurrent motor and vocal tics; it is accompanied by structural and functiona...

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Bibliographic Details
Main Authors: Kantiya Jindachomthong, Chengran Yang, Yuegao Huang, Daniel Coman, Maximiliano Rapanelli, Fahmeed Hyder, Joseph Dougherty, Luciana Frick, Christopher Pittenger
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-11-01
Series:Frontiers in Molecular Neuroscience
Subjects:
animal model
tourette syndrome
histamine
myelin
striatum
Online Access:https://www.frontiersin.org/articles/10.3389/fnmol.2022.1037481/full

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https://www.frontiersin.org/articles/10.3389/fnmol.2022.1037481/full

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