FMR1 promotes the progression of colorectal cancer cell by stabilizing EGFR mRNA in an m6A-dependent manner

Abstract FMR1, a new m6A reader, is known to be involved in the regulation of cancer progression. However, its role, regulatory mechanism, and clinical significance in colorectal cancer (CRC) are elusive. Here, we showed that FMR1 was upregulated in CRC, and it promoted proliferation and metastasis...

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Bibliographic Details
Main Authors: Yuhan Hu, Qingzu Gao, Shuai Ma, Pei Yu, Shuang Ding, Xiaofei Yao, Zheying Zhang, Shuya Lu, Manman Lu, Jinghang Zhang, Yanling Wang, Xinlai Qian, Jiateng Zhong
Format: Article
Language:English
Published: Nature Publishing Group 2022-11-01
Series:Cell Death and Disease
Online Access:https://doi.org/10.1038/s41419-022-05391-7