Formulation Strategies to Improve Nose-to-Brain Delivery of Donepezil

Formulation Strategies to Improve Nose-to-Brain Delivery of Donepezil

Donepezil (DPZ) is widely used in the treatment of Alzheimer’s disease in tablet form for oral administration. The pharmacological efficacy of this drug can be enhanced by the use of intranasal administration because this route makes bypassing the blood⁻brain barrier (BBB) possib...

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Bibliographic Details
Main Authors: Lupe Carolina Espinoza, Marcelle Silva-Abreu, Beatriz Clares, María José Rodríguez-Lagunas, Lyda Halbaut, María-Alexandra Cañas, Ana Cristina Calpena
Format: Article
Language:English
Published: MDPI AG 2019-02-01
Series:Pharmaceutics
Subjects:
Donepezil
Alzheimer’s disease
nanoemulsion
mucoadhesion
nose-to-brain
Pluronic F-127
Online Access:https://www.mdpi.com/1999-4923/11/2/64

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https://www.mdpi.com/1999-4923/11/2/64

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