Histone Demethylase KDM5C Drives Prostate Cancer Progression by Promoting EMT

Histone Demethylase KDM5C Drives Prostate Cancer Progression by Promoting EMT

Prostate cancer (PCa) poses a major public health problem in men. Metastatic PCa is incurable, and ultimately threatens the life of many patients. Mutations in tumor suppressor genes and oncogenes are important for PCa progression, whereas the role of epigenetic factors in prostate carcinogenesis is...

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Bibliographic Details
Main Authors: Anna-Lena Lemster, Elisabeth Sievers, Helen Pasternack, Pamela Lazar-Karsten, Niklas Klümper, Verena Sailer, Anne Offermann, Johannes Brägelmann, Sven Perner, Jutta Kirfel
Format: Article
Language:English
Published: MDPI AG 2022-04-01
Series:Cancers
Subjects:
prostate cancer
CRPC
histone demethylase
KDM5C
epithelial-to-mesenchymal transition
signaling pathway
Online Access:https://www.mdpi.com/2072-6694/14/8/1894

Internet

https://www.mdpi.com/2072-6694/14/8/1894

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