Efflux Pump-Binding 4(3-Aminocyclobutyl)Pyrimidin-2-Amines Are Colloidal Aggregators

Efflux Pump-Binding 4(3-Aminocyclobutyl)Pyrimidin-2-Amines Are Colloidal Aggregators

Efflux pumps are a relevant factor in antimicrobial resistance. In <i>E. coli</i>, the tripartite efflux pump AcrAB-TolC removes a chemically diverse set of antibiotics from the bacterium. Therefore, small molecules interfering with efflux pump function are considered adjuvants for impro...

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Bibliographic Details
Main Authors: Tania Szal, Shweta Singh Chauhan, Philipp Lewe, Fatima-Zahra Rachad, Marina Madre, Laura Paunina, Susanne Witt, Ramakrishnan Parthasarathi, Björn Windshügel
Format: Article
Language:English
Published: MDPI AG 2023-06-01
Series:Biomolecules
Subjects:
efflux pumps
AcrA
efflux pump inhibitor
<i>E. coli</i>
virtual screening
antimicrobial studies
Online Access:https://www.mdpi.com/2218-273X/13/6/1000

Internet

https://www.mdpi.com/2218-273X/13/6/1000

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