Chenodeoxycholic acid suppresses the activation of acetyl-coenzyme A carboxylase-α gene transcription by the liver X receptor agonist T0-901317

Chenodeoxycholic acid suppresses the activation of acetyl-coenzyme A carboxylase-α gene transcription by the liver X receptor agonist T0-901317

The therapeutic utility of liver X receptor (LXR) agonists in treating atherosclerosis is limited by an undesired accumulation of triglycerides in the blood and liver. This effect is caused by an increase in the transcription of genes involved in fatty acid synthesis. Here, we show that the primary...

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Bibliographic Details
Main Authors: Saswata Talukdar, Sushant Bhatnagar, Sami Dridi, F. Bradley Hillgartner
Format: Article
Language:English
Published: Elsevier 2007-12-01
Series:Journal of Lipid Research
Subjects:
fatty acid synthesis
sterol-regulatory element binding protein
fibroblast growth factor-19
peroxisome proliferator-activated receptor γ coactivator-1α
p38 mitogen-activated protein kinase
extracellular signal-regulated kinase
Online Access:http://www.sciencedirect.com/science/article/pii/S0022227520429165

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http://www.sciencedirect.com/science/article/pii/S0022227520429165

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