Pharmacokinetic/pharmacodynamic target attainment of intravenous β-lactam regimens against Gram-negative bacteria isolated in a Brazilian teaching hospital

Pharmacokinetic/pharmacodynamic target attainment of intravenous β-lactam regimens against Gram-negative bacteria isolated in a Brazilian teaching hospital

ABSTRACTINTRODUCTION: Monte Carlo simulations have been used for selecting optimal antibiotic regimens for treatment of bacterial infections. The aim of this study was to assess the pharmacokinetic and pharmacodynamic target attainment of intravenous β-lactam regimens commonly used to treat bloodstr...

Full description

Bibliographic Details
Main Authors:	Guilherme Henrique Furtado, Leandro Cardinal, Rodrigo Spineli Macedo, Juliana Oliveira Silva, Eduardo Alexandrino Medeiros, Joseph Levente Kuti, David Paul Nicolau
Format:	Article
Language:	English
Published:	Sociedade Brasileira de Medicina Tropical (SBMT) 2015-10-01
Series:	Revista da Sociedade Brasileira de Medicina Tropical
Subjects:	Monte Carlo simulation Pharmacodynamics Gram-negative bacteria Bloodstream infections
Online Access:	http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0037-86822015000500539&lng=en&tlng=en

Similar Items

Pharmacokinetic/Pharmacodynamic Adequacy of Novel β-Lactam/β-Lactamase Inhibitors against Gram-Negative Bacterial in Critically Ill Patients
by: Ruiying Han, et al.
Published: (2021-08-01)

Impact of Beta-Lactam Target Attainment on Resistance Development in Patients with Gram-Negative Infections
by: Nicole F. Maranchick, et al.
Published: (2023-12-01)

Pharmacokinetics/pharmacodynamics of polymyxin B in patients with bloodstream infection caused by carbapenem-resistant Klebsiella pneumoniae
by: Zhenwei Yu, et al.
Published: (2022-12-01)

Pharmacodynamic comparison of different antimicrobial regimens against Staphylococcus aureus bloodstream infections with elevated vancomycin minimum inhibitory concentration
by: Thaina Miranda da Costa, et al.
Published: (2020-01-01)

A strategy for designing voriconazole dosage regimens to prevent invasive pulmonary aspergillosis based on a cellular pharmacokinetics/pharmacodynamics model
by: Taotao Wang, et al.
Published: (2018-06-01)

Pharmacodynamics of Ceftibuten: An Assessment of an Oral Cephalosporin against Enterobacterales in a Neutropenic Murine Thigh Model
by: Maxwell J. Lasko, et al.
Published: (2021-02-01)

Pharmacokinetic/pharmacodynamic comparison between generic and brand-name levofloxacin based on Monte Carlo simulation
by: Pan Ma, et al.
Published: (2023-06-01)

<i>β</i>-Lactam Pharmacokinetic/Pharmacodynamic Target Attainment in Intensive Care Unit Patients: A Prospective, Observational, Cohort Study
by: Romain Guilhaumou, et al.
Published: (2023-08-01)

Optimizing intravenous fosfomycin dosing in combination with carbapenems for treatment of Pseudomonas aeruginosa infections in critically ill patients based on pharmacokinetic/pharmacodynamic (PK/PD) simulation
by: O. Asuphon, et al.
Published: (2016-09-01)

Pharmacokinetic/Pharmacodynamic Based Breakpoints of Polymyxin B for Bloodstream Infections Caused by Multidrug-Resistant Gram-Negative Pathogens
by: Xingchen Bian, et al.
Published: (2022-01-01)

Integrated pharmacokinetic–pharmacodynamic modeling to evaluate empiric carbapenem therapy in bloodstream infections
by: Lim TP, et al.
Published: (2018-09-01)

Pharmacodynamic Thresholds for Beta-Lactam Antibiotics: A Story of Mouse Versus Man
by: Angela V. Berry, et al.
Published: (2022-03-01)

A pharmacodynamic strategy to optimize empirical antibiotic therapy for gram-negative bacteria in a Brazilian Intensive Care Unit
by: Carlos R.V. Kiffer, et al.

Pharmacokinetics and pharmacodynamics of intravenous artesunate during severe malaria treatment in Ugandan adults
by: Byakika-Kibwika Pauline, et al.
Published: (2012-04-01)

Evaluation of Piperacillin/Sulbactam, Piperacillin/Tazobactam and Cefoperazone/Sulbactam Dosages in Gram-Negative Bacterial Bloodstream Infections by Monte Carlo Simulation
by: Xueting Wang, et al.
Published: (2023-02-01)

Evaluating the efficacy of different antibiotics against Neisseria gonorrhoeae: a pharmacokinetic/pharmacodynamic analysis using Monte Carlo simulation
by: Jiaojiao Zhong, et al.
Published: (2024-01-01)

Clinical Efficacy and Cost-Effectiveness of β-Lactam/β-Lactamase Inhibitor Combinations and Carbapenems in Liver Cirrhosis Patients with Gram-Negative Bacteria Bloodstream Infection
by: Dong Y, et al.
Published: (2020-05-01)

A Pharmacokinetic and Pharmacodynamic Study on Intravenous Cefazedone Sodium in Patients with Community-acquired Pneumonia
by: Lei Gao, et al.
Published: (2015-01-01)

Bloodstream Infection and Gram-Negative Resistance: The Role for Newer Antibiotics
by: Jessica Waters, et al.
Published: (2023-05-01)

Pharmacokinetics and Pharmacodynamics of Colistin Methanesulfonate in Healthy Chinese Subjects after Multi-Dose Regimen
by: Yaxin Fan, et al.
Published: (2022-06-01)

Ivermectin: Difficulties in resolving pharmacokinetic and pharmacodynamic relationships in onchocerciasis
by: E N Shu, et al.
Published: (2004-01-01)

Pharmacokinetics–pharmacodynamics issues relevant for the clinical use of beta-lactam antibiotics in critically ill patients
by: Rui Pedro Veiga, et al.
Published: (2018-09-01)

Pharmacokinetic and pharmacodynamic modeling of oral mitiglinide on glucose lowering in healthy Chinese volunteers
by: Shijia Liu, et al.
Published: (2017-07-01)

Bloodstream gram-negative bacterial infections in adult patients with leukemia: A retrospective review of medical records in a tertiary care hospital in Western Saudi Arabia
by: Reyan Merdad, et al.
Published: (2023-10-01)

Pharmacodynamics and pharmacokinetics of nalbuphine in xylazine‑sedated horses
by: Amal Hammad, et al.
Published: (2023-05-01)

Rapid Detection of Specific Gram-negative Microorganisms Causing Bloodstream Infections in Children with the Microarray Method
by: Gülhadiye Avcu, et al.
Published: (2020-06-01)

Risk factors for nosocomial bloodstream infection caused by multidrug resistant gram-negative bacilli in pediatrics
by: Mariana V. Arnoni, et al.

Pharmacodynamics of Five Anthraquinones (Aloe-emodin, Emodin, Rhein, Chysophanol, and Physcion) and Reciprocal Pharmacokinetic Interaction in Rats with Cerebral Ischemia
by: Rong-Rong Li, et al.
Published: (2019-05-01)

Prediction of marbofloxacin dosage for the pig pneumonia pathogens Actinobacillus pleuropneumoniae and Pasteurella multocida by pharmacokinetic/pharmacodynamic modelling
by: Lucy Dorey, et al.
Published: (2017-07-01)

Pulmonary Pharmacokinetic and Pharmacodynamic Evaluation of Ampicillin/Sulbactam Regimens for Pneumonia Caused by Various Bacteria, including <i>Acinetobacter baumannii</i>
by: Tetsushu Onita, et al.
Published: (2023-02-01)

Isavuconazole Pharmacokinetics and Pharmacodynamics in Children
by: Hirsh Elhence, et al.
Published: (2022-12-01)

ADME, Pharmacokinetic Scaling, Pharmacodynamic and Prediction of Human Dose and Regimen of Novel Antiviral Drugs
by: Tridib Chaira, et al.
Published: (2023-04-01)

Pharmacokinetic–Pharmacodynamic Model for the Testosterone-Suppressive Effect of Leuprolide in Normal and Prostate Cancer Rats
by: Dong-Seok Lee, et al.
Published: (2018-04-01)

Pharmacokinetic/Pharmacodynamic Model of Neutropenia in Real-Life Palbociclib-Treated Patients
by: Alexandre Le Marouille, et al.
Published: (2021-10-01)

Bloodstream infections in pediatric patients with acute leukemia: Emphasis on gram-negative bacteria infections
by: Fu-Chun Kuo, et al.
Published: (2017-08-01)

Oritavancin as sequential therapy for Gram-positive bloodstream infections
by: Williams Monier Texidor, et al.
Published: (2024-01-01)

Pharmacokinetics and pharmacodynamics of linezolid in plasma/cerebrospinal fluid in patients with cerebral hemorrhage after lateral ventricular drainage by Monte Carlo simulation
by: Wu X, et al.
Published: (2018-06-01)

Optimizing tylosin dosage for co-infection of Actinobacillus pleuropneumoniae and Pasteurella multocida in pigs using pharmacokinetic/pharmacodynamic modeling
by: Eon-Bee Lee, et al.
Published: (2023-09-01)

Pharmacokinetic/Pharmacodynamic Dosage Individualization of Suppressive Beta-Lactam Therapy Administered by Subcutaneous Route in Patients With Prosthetic Joint Infection
by: Sylvain Goutelle, et al.
Published: (2021-03-01)

Population Pharmacokinetic Modeling and Pharmacodynamic Target Attainment Simulation of Piperacillin/Tazobactam for Dosing Optimization in Late Elderly Patients with Pneumonia
by: Noriyuki Ishihara, et al.
Published: (2020-03-01)