Integration of multiple biological contexts reveals principles of synthetic lethality that affect reproducibility

Integration of multiple biological contexts reveals principles of synthetic lethality that affect reproducibility

Defining robust, penetrant synthetic lethal targets for cancer therapeutics is a challenge. Here, the authors demonstrate how pathway, genetic and cellular context dictates dependence on cancer targets.

Bibliographic Details
Main Authors: Angel A. Ku, Hsien-Ming Hu, Xin Zhao, Khyati N. Shah, Sameera Kongara, Di Wu, Frank McCormick, Allan Balmain, Sourav Bandyopadhyay
Format: Article
Language:English
Published: Nature Portfolio 2020-05-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-020-16078-y

Internet

https://doi.org/10.1038/s41467-020-16078-y

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