BM-MSCs alleviate diabetic nephropathy in male rats by regulating ER stress, oxidative stress, inflammation, and apoptotic pathways

BM-MSCs alleviate diabetic nephropathy in male rats by regulating ER stress, oxidative stress, inflammation, and apoptotic pathways

Introduction: Diabetic nephropathy (DN), a chronic kidney disease, is a major cause of end-stage kidney disease worldwide. Mesenchymal stem cells (MSCs) have become a promising option to mitigate several diabetic complications.Methods: In this study, we evaluated the therapeutic potential of bone ma...

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Main Authors: Tarek Khamis, Adel Abdelkhalek, Hussein Abdellatif, Nourelden Dwidar, Ahmed Said, Rama Ahmed, Kerolos Wagdy, Rowina Elgarhy, Rawan Eltahan, Hisham Mohamed, Eman Said Amer, Maria Hanna, Tarek Ragab, Abdallah Kishk, Judy Wael, Eyad Sarhan, Linda Saweres, Mohamed Reda, Sara Elkomy, Abdalah Mohamed, Abdullah Samy, Ateya Khafaga, Youliana Shaker, Hamdy Yehia, Asma Alanazi, Mohammed Alassiri, Emil Tîrziu, Iulia Maria Bucur, Ahmed Hamed Arisha
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-11-01
Series:Frontiers in Pharmacology
Subjects:
diabetic nephropathy
mesenchymal stem cells
bone marrow-derived mesenchymal stem cells
diabetes
apoptosis
ER stress
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2023.1265230/full

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https://www.frontiersin.org/articles/10.3389/fphar.2023.1265230/full

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