Co-delivery of Bmi1 small interfering RNA with ursolic acid by folate receptor-targeted cationic liposomes enhances anti-tumor activity of ursolic acid in vitro and in vivo

Co-delivery of Bmi1 small interfering RNA with ursolic acid by folate receptor-targeted cationic liposomes enhances anti-tumor activity of ursolic acid in vitro and in vivo

Overexpression of Bmi1 gene is an important feature of cancer stem cell in various human tumors. Therefore, Bmi1 gene can be a potential target for small interfering RNA (siRNA) mediated cancer therapy. Ursolic acid (UA) as a natural product plays a pivotal role in anti-tumor field, although its per...

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Bibliographic Details
Main Authors: Weijie Li, Ruicong Yan, Yong Liu, Chuanchuan He, Xiaojuan Zhang, Yao Lu, Muhammad Waseem Khan, Chuanrui Xu, Tan Yang, Guangya Xiang
Format: Article
Language:English
Published: Taylor & Francis Group 2019-01-01
Series:Drug Delivery
Subjects:
liposome
bmi1 sirna
ursolic acid
folate receptor
tumor targeting
Online Access:http://dx.doi.org/10.1080/10717544.2019.1645244

Internet

http://dx.doi.org/10.1080/10717544.2019.1645244

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