Pathogenic connexin-31 forms constitutively active hemichannels to promote necrotic cell death.

Pathogenic connexin-31 forms constitutively active hemichannels to promote necrotic cell death.

Mutations in Connexin-31 (Cx31) are associated with multiple human diseases including erythrokeratodermia variabilis (EKV). The molecular action of Cx31 pathogenic mutants remains largely elusive. We report here that expression of EKV pathogenic mutant Cx31R42P induces cell death with necrotic chara...

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Autori principali: Jingwei Chi, Li Li, Mujun Liu, Jieqiong Tan, Chengyuan Tang, Qian Pan, Danling Wang, Zhuohua Zhang
Natura: Articolo
Lingua:English
Pubblicazione: Public Library of Science (PLoS) 2012-01-01
Serie:PLoS ONE
Accesso online:http://europepmc.org/articles/PMC3290583?pdf=render

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http://europepmc.org/articles/PMC3290583?pdf=render

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