Antiproliferative and apoptotic effect of LY2090314, a GSK-3 inhibitor, in neuroblastoma in vitro

Antiproliferative and apoptotic effect of LY2090314, a GSK-3 inhibitor, in neuroblastoma in vitro

Abstract Background Neuroblastoma (NB) is a devastating disease. Despite recent advances in the treatment of NB, about 60% of high-risk NB will have relapse and therefore long-term event free survival is very minimal. We have reported that targeting glycogen synthase kinase-3 (GSK-3) may be a potent...

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Bibliographic Details
Main Authors: Selvi Kunnimalaiyaan, Victoriana K. Schwartz, Iris Alao Jackson, T. Clark Gamblin, Muthusamy Kunnimalaiyaan
Format: Article
Language:English
Published: BMC 2018-05-01
Series:BMC Cancer
Subjects:
GSK-3 inhibitor
Neuroblastoma
GSK-3 alpha
GSK-3 beta
Apoptosis
Online Access:http://link.springer.com/article/10.1186/s12885-018-4474-7

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http://link.springer.com/article/10.1186/s12885-018-4474-7

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