Elementary properties of Ca2+ channels and their influence on multivesicular release and phase-locking at auditory hair cell ribbon synapses

Elementary properties of Ca2+ channels and their influence on multivesicular release and phase-locking at auditory hair cell ribbon synapses

Voltage-gated calcium (Cav1.3) channels in mammalian inner hair cells (IHCs) open in response to sound and the resulting Ca2+ entry triggers the release of the neurotransmitter glutamate onto afferent terminals. At low to mid sound frequencies cell depolarization follows the sound sinusoid and puls...

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Bibliographic Details
Main Authors: Jacopo eMagistretti, Paolo eSpaiardi, Stuart L Johnson, Sergio eMasetto
Format: Article
Language:English
Published: Frontiers Media S.A. 2015-04-01
Series:Frontiers in Cellular Neuroscience
Subjects:
Cochlea
patch-clamp
phase locking
ribbon synapse
inner hair cell
Ca2+ channel
Online Access:http://journal.frontiersin.org/Journal/10.3389/fncel.2015.00123/full

Internet

http://journal.frontiersin.org/Journal/10.3389/fncel.2015.00123/full

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