Function-altering SNPs in the human multidrug transporter gene ABCB1 identified using a Saccharomyces-based assay.
The human ABCB1 (MDR1)-encoded multidrug transporter P-glycoprotein (P-gp) plays a major role in disposition and efficacy of a broad range of drugs including anticancer agents. ABCB1 polymorphisms could therefore determine interindividual variability in resistance to these drugs. To test this hypoth...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Public Library of Science (PLoS)
2007-03-01
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| Series: | PLoS Genetics |
| Online Access: | http://europepmc.org/articles/PMC1817653?pdf=render |