Transcriptomic changes underlying EGFR inhibitor resistance in human and mouse models of basal-like breast cancer

Transcriptomic changes underlying EGFR inhibitor resistance in human and mouse models of basal-like breast cancer

Abstract The goals of this study were to identify transcriptomic changes that arise in basal-like breast cancer cells during the development of resistance to epidermal growth factor receptor inhibitors (EGFRi) and to identify drugs that are cytotoxic once EGFRi resistance occurs. Human patient-deriv...

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Bibliographic Details
Main Authors: Narmeen S. Rashid, David C. Boyd, Amy L. Olex, Jacqueline M. Grible, Alex K. Duong, Mohammad A. Alzubi, Julia E. Altman, Tess J. Leftwich, Aaron D. Valentine, Nicole S. Hairr, Emily K. Zboril, Timothy M. Smith, Adam D. Pfefferle, Mikhail G. Dozmorov, J. Chuck Harrell
Format: Article
Language:English
Published: Nature Portfolio 2022-12-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-022-25541-3

Internet

https://doi.org/10.1038/s41598-022-25541-3

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