Quantitative analysis of preferential utilization of AAV ITR as the packaging terminal signal

Quantitative analysis of preferential utilization of AAV ITR as the packaging terminal signal

Genetic engineering advances have led to recombinant adeno-associated virus (rAAV) becoming an invaluable tool for the development of effective gene therapies. The production of rAAV is susceptible to off-target heterogeneous packaging, the effects of which are still being understood. Here, rAAV vec...

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Bibliographic Details
Main Authors: Xin Li, Lohra Mickelle Miller, Matthew Chrzanowski, Jiahe Tian, Martin F. Jarrold, Roland W. Herzog, Weidong Xiao, Benjamin Draper, Junping Zhang
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-12-01
Series:Frontiers in Bioengineering and Biotechnology
Subjects:
adeno-associated virus
invert terminal repeat
small genome
packaging signal
replicative intermediates
Online Access:https://www.frontiersin.org/articles/10.3389/fbioe.2023.1327433/full

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https://www.frontiersin.org/articles/10.3389/fbioe.2023.1327433/full

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