Genome-Derived Cytosolic DNA Mediates Type I Interferon-Dependent Rejection of B Cell Lymphoma Cells

Genome-Derived Cytosolic DNA Mediates Type I Interferon-Dependent Rejection of B Cell Lymphoma Cells

The DNA damage response (DDR) induces the expression of type I interferons (IFNs), but the underlying mechanisms are poorly understood. Here, we show the presence of cytosolic DNA in different mouse and human tumor cells. Treatment of cells with genotoxic agents increased the levels of cytosolic DNA...

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Bibliographic Details
Main Authors: Yu J. Shen, Nina Le Bert, Anuja A. Chitre, Christine Xing’Er Koo, Xing H. Nga, Samantha S.W. Ho, Muznah Khatoo, Nikki Y. Tan, Ken J. Ishii, Stephan Gasser
Format: Article
Language:English
Published: Elsevier 2015-04-01
Series:Cell Reports
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124715003204

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http://www.sciencedirect.com/science/article/pii/S2211124715003204

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