An extensive pharmacological evaluation of novel anti-nociceptive and IL-6 targeted anti-inflammatory guaiane-type sesquiterpenoids from Cinnamomum migao H. W. Li through in-depth in-vitro, ADMET, and molecular docking studies

An extensive pharmacological evaluation of novel anti-nociceptive and IL-6 targeted anti-inflammatory guaiane-type sesquiterpenoids from Cinnamomum migao H. W. Li through in-depth in-vitro, ADMET, and molecular docking studies

Guaiane-type sesquiterpenoids are most prevalent in the genus Cinnamomum. Hence this study investigates the structures, anti-nociceptive and IL-6 targeted anti-inflammatory potential of three novels C-14 guaiane-type sesquiterpenoids and two new monoterpenoids, isolated from Cinnamomum migao. The st...

Full description

Bibliographic Details
Main Authors: Ishaq Muhammad, Syed Shams ul Hassan, Wen-Jing Xu, Guo-Li Tu, Hua-Jun Yu, Xue Xiao, Shi-Kai Yan, Hui-Zi Jin, Simona Bungau
Format: Article
Language:English
Published: Elsevier 2023-08-01
Series:Biomedicine & Pharmacotherapy
Subjects:
Cinnamomum migao H. W. Li
Guaiane-sesquiterpenoids
Anti-inflammatory activity
Anti-nociceptive effect
ADMET
Molecular dynamic simulations
Online Access:http://www.sciencedirect.com/science/article/pii/S0753332223007369

Internet

http://www.sciencedirect.com/science/article/pii/S0753332223007369

Similar Items