Synthesis of 2-(2-Aminopyrimidine)-2,2-difluoroethanols as Potential Bioisosters of Salicylidene Acylhydrazides

Synthesis of 2-(2-Aminopyrimidine)-2,2-difluoroethanols as Potential Bioisosters of Salicylidene Acylhydrazides

Salicylidene acylhydrazides are inhibitors of type III secretion in several Gram-negative pathogens. To further develop the salicylidene acylhydrazides, scaffold hopping was applied to replace the core fragment of the compounds. The novel 2-(2-amino-pyrimidine)-2,2-difluoroethanol scaffold was ident...

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Bibliographic Details
Main Authors: Markus K. Dahlgren, Christopher T. Öberg, Erika A. Wallin, Pär G. Janson, Mikael Elofsson
Format: Article
Language:English
Published: MDPI AG 2010-06-01
Series:Molecules
Subjects:
scaffold hopping
Reformatsky reaction
salicylidene acylhydrazide
type III secretion
Online Access:http://www.mdpi.com/1420-3049/15/6/4423/

Internet

http://www.mdpi.com/1420-3049/15/6/4423/

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