Single time point comparisons in longitudinal randomized controlled trials: power and bias in the presence of missing data

Single time point comparisons in longitudinal randomized controlled trials: power and bias in the presence of missing data

Abstract Background The primary analysis in a longitudinal randomized controlled trial is sometimes a comparison of arms at a single time point. While a two-sample t-test is often used, missing data are common in longitudinal studies and decreases power by reducing sample size. Mixed models for repe...

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Bibliographic Details
Main Authors: Erin L. Ashbeck, Melanie L. Bell
Format: Article
Language:English
Published: BMC 2016-04-01
Series:BMC Medical Research Methodology
Subjects:
Complete-case
Longitudinal
Mean response profile
Missing data
Mixed model
Power
Online Access:http://link.springer.com/article/10.1186/s12874-016-0144-0

Internet

http://link.springer.com/article/10.1186/s12874-016-0144-0

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