3123 TGFbeta, Early Cytokine Dysregulation, and Airway Smooth Muscle Dysfunction in Cystic Fibrosis

OBJECTIVES/SPECIFIC AIMS: This study aims to first describe the unique cytokine profile and TGFbeta levels of young children with CF, then understand the pathologic effects of TGFbeta on lung function in a CF animal model. These powerful translational studies linking observations in clinical disease...

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Bibliographic Details
Main Authors: Elizabeth L Kramer, Rhonda Szczesniak, Weiji Su, Satish Madala, Kristin Hudock, Cynthia Davidson, Alicia Ostmann, Lauren Strecker, John P. Clancy
Format: Article
Language:English
Published: Cambridge University Press 2019-03-01
Series:Journal of Clinical and Translational Science
Online Access:https://www.cambridge.org/core/product/identifier/S2059866119000554/type/journal_article