Genetic and Pharmacological YAP Activation Induces Proliferation and Improves Survival in Human Induced Pluripotent Stem Cell-Derived Cardiomyocytes

Genetic and Pharmacological YAP Activation Induces Proliferation and Improves Survival in Human Induced Pluripotent Stem Cell-Derived Cardiomyocytes

Cardiomyocyte loss following myocardial infarction cannot be addressed with current clinical therapies. Cell therapy with induced pluripotent stem cell-derived cardiomyocytes (iPSC-CMs) is a potential approach to replace cardiomyocyte loss. However, engraftment rates in pre-clinical studies have bee...

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Bibliographic Details
Main Authors: Thuy Anh Bui, Nicholas Stafford, Delvac Oceandy
Format: Article
Language:English
Published: MDPI AG 2023-08-01
Series:Cells
Subjects:
induced pluripotent stem cells
iPSC-derived cardiomyocytes
Yes-associated protein
Hippo signalling pathway
cell proliferation
apoptosis
Online Access:https://www.mdpi.com/2073-4409/12/17/2121

Internet

https://www.mdpi.com/2073-4409/12/17/2121

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