Structural Basis for Design of New Purine-Based Inhibitors Targeting the Hydrophobic Binding Pocket of Hsp90

Structural Basis for Design of New Purine-Based Inhibitors Targeting the Hydrophobic Binding Pocket of Hsp90

Inhibition of the molecular chaperone heat shock protein 90 (Hsp90) represents a promising approach for cancer treatment. BIIB021 is a highly potent Hsp90 inhibitor with remarkable anticancer activity; however, its clinical application is limited by lack of potency and response. In this study, we ai...

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Bibliographic Details
Main Authors: Sang Chul Shin, Ashraf K. El-Damasy, Ju Hyeon Lee, Seon Hee Seo, Ji Hyun Kim, Young Ho Seo, Yuri Lee, Ji Hoon Yu, Eun Kyoung Bang, Eunice EunKyeong Kim, Gyochang Keum
Format: Article
Language:English
Published: MDPI AG 2020-12-01
Series:International Journal of Molecular Sciences
Subjects:
Hsp90 inhibitors
BIIB021 analogs
isoxazole
hydrophobic binding pocket
X-ray crystallography
Online Access:https://www.mdpi.com/1422-0067/21/24/9377

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https://www.mdpi.com/1422-0067/21/24/9377

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